Comparative sensitivity of immunodiagnostic tests <i>in vivo</i> (Mantoux and RTA) and <i>in vitro</i> (QuantiFERON – GIT) in children with chronic nonspecific bronchopulmonary pathology associated with various tuberculosis

Aim. Selection and combination of immunodiagnostic tests to detect active tuberculosis (TB) in children with concomitant bronchopulmonary pathologies. Materials methods. A prospective study adolescents ( n = 236) was conducted, which included cases localized pulmonary tuberculosis; associated allergic or infectious inflammatory forms chronic nonspecific lung diseases (CNSLD); under a significant absence TB but the presence Mycobacterium tuberculosis. All patients underwent by Mantoux test, recombinant allergen (RTA) QuantiFERON – GIT. Results. RTA were found exhibit high sensitivity both pathologies without such Differences observed results obtained test tuberculosis-associated pathology those The may be positive as result many factors, other than infection. Thus, infectious-inflammatory lungs an altered test. Such require vitro diagnostics Quanti- FERON whose is despite CNSLD. Conclusions. Children CNSLD should undergo examination stages based on vivo tests, when necessary. at first stage.